These unpigmented and immunocompetent mice allow for ready manipulation of the skin, application of topical agents, and exposure to UVR, as well as easy visualization of the cutaneous response. ![]() Although a variety of hairless strains have been developed, outbred SKH1 mice are the most widely used in dermatologic research. Mutations in the human ortholog have also been associated with congenital alopecia. ![]() In the mouse, several null and hypomorphic Hr alleles have been identified resulting in hairlessness in homozygous animals, characterized by alopecia developing after a single cycle of relatively normal hair growth. The hairless ( Hr) gene encodes a transcriptional co-repressor highly expressed in the mammalian skin.
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