These unpigmented and immunocompetent mice allow for ready manipulation of the skin, application of topical agents, and exposure to UVR, as well as easy visualization of the cutaneous response. Although a variety of hairless strains have been developed, outbred SKH1 mice are the most widely used in dermatologic research. Mutations in the human ortholog have also been associated with congenital alopecia. In the mouse, several null and hypomorphic Hr alleles have been identified resulting in hairlessness in homozygous animals, characterized by alopecia developing after a single cycle of relatively normal hair growth. The hairless ( Hr) gene encodes a transcriptional co-repressor highly expressed in the mammalian skin.
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